Crystal structure of febuxostat marketed polymorph determined by electron diffraction and reinforced by X-ray crystallography

Author:

Ungur Doriana T.12ORCID,Lanza Arianna3ORCID,Stam Danny4,Guguta Carmen5,Iordache Coca2,Fruth Victor6ORCID,Santiso-Quinones Gustavo47,Pop Mihaela M.2ORCID

Affiliation:

1. Doctoral School in Integrative Biology, Faculty of Biology and Geology, “Babeş-Bolyai” University, Cluj-Napoca, Romania

2. TeraCrystal SRL, 67-103 Donat, 400293 Cluj-Napoca, Romania

3. University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark

4. ELDICO Scientific AG, Park Innovaare, 5234 Villigen, Switzerland

5. Technobis Crystallization Systems BV, Pyrietstraat 2, 1812 SC Alkmaar, The Netherlands

6. “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, Bucharest, 060021, Romania

7. Crystallise! AG, Hegenheimermattweg 167A, 4123 Allschwil, Switzerland

Abstract

The crystal structure of the febuxostat marketed polymorph solved by ED and SC-XRD was important in understanding the compound's conformational polymorphism.

Funder

Ministry of Education and Research, Romania

Publisher

Royal Society of Chemistry (RSC)

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