BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma-Reference-Cited by-同舟云学术

BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma

Published:2021 Issue:5 Volume:9 Page:1668-1682
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Vantucci Casey E.¹²³⁴⁵,Krishan Laxminarayanan⁵⁶³⁴,Cheng Albert⁵⁶³⁴⁷,Prather Ayanna⁵⁶³⁴,Roy Krishnendu¹²³⁴⁵^ORCID,Guldberg Robert E.⁸⁹¹⁰⁴^ORCID

Affiliation:

1. Wallace H. Coulter Department of Biomedical Engineering

2. Georgia Institute of Technology and Emory University

3. Atlanta

4. USA

5. Parker H. Petit Institute for Bioengineering and Bioscience

6. Georgia Institute of Technology

7. George W. Woodruff School of Mechanical Engineering

8. Knight Campus for Accelerating Scientific Impact

9. University of Oregon

10. Eugene

Abstract

Bone nonunions remain compelling orthopedic challenges. Bone morphogenetic protein-2 (BMP-2) delivered in a heparin microparticle (HMP) delivery system improved local bone regeneration compared to BMP-2 delivered in the clinical standard collagen sponge.

Funder

Armed Forces Institute of Regenerative Medicine

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01728K

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