<i>N</i>-7′ methylation in apramycin: its biosynthesis and biological role-Reference-Cited by-同舟云学术

N-7′ methylation in apramycin: its biosynthesis and biological role

Published:2022 Issue:10 Volume:9 Page:2708-2713
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Qian¹,He Chang¹,Sun Jing¹,Deng Zixin¹,Yu Yi¹^ORCID

Affiliation:

1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P. R. China

Abstract

This work characterized N-7′ methylation in apramycin's assembly line, which fills in the final step at the pseudotrisaccharide stage of the apramycin biosynthetic pathway and indicates the significant biological role of the N-7′ methyl group.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00260D

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