Photoactive chlorin e6 is a multifunctional modulator of amyloid-β aggregation and toxicity via specific interactions with its histidine residues-Reference-Cited by-同舟云学术

Photoactive chlorin e6 is a multifunctional modulator of amyloid-β aggregation and toxicity via specific interactions with its histidine residues

Published:2019 Issue:1 Volume:10 Page:208-217
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Leshem Guy¹²³⁴,Richman Michal¹²³⁴,Lisniansky Elvira¹²³⁴,Antman-Passig Merav¹²³⁴,Habashi Maram¹²³⁴,Gräslund Astrid⁵⁶⁷⁸⁹,Wärmländer Sebastian K. T. S.⁵⁶⁷⁸⁹,Rahimipour Shai¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Bar-Ilan University

3. Ramat-Gan 5290002

4. Israel

5. Department of Biochemistry and Biophysics

6. Arrhenius Laboratories

7. Stockholm University

8. S-106 91 Stockholm

9. Sweden

Abstract

Photoactive chlorin e6 selectively damage the histidine residues of amyloid-β and reduce its aggregation and toxicity even in the presence of Cu ions.

Funder

Swedish Research Council

Magnus Bergvall Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC01992D

Reference75 articles.

1. The amyloid hypothesis of Alzheimer's disease at 25 years

2. Diffusible, nonfibrillar ligands derived from A 1-42 are potent central nervous system neurotoxins