Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent-Reference-Cited by-同舟云学术

Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent

Published:2023 Issue:23 Volume:13 Page:15999-16011
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kumamoto Hiroki¹,Higashi-Kuwata Nobuyo²^ORCID,Hayashi Sanae³,Das Debananda⁴,Bulut Haydar⁴,Tokuda Ryoh⁵,Imoto Shuhei⁵,Onitsuka Kengo²,Honda Yuka⁶,Odanaka Yuki⁶,Shimbara-Matsubayashi Satoko⁶,Haraguchi Kazuhiro¹,Tanaka Yasuhito³,Mitsuya Hiroaki²⁴⁷

Affiliation:

1. Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan

2. Department of Refractory Viral Infection, National Center for Global Health & Medicine Research Institute, Tokyo, Japan

3. Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

4. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

5. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan

6. School of Pharmacy, Showa University, Tokyo, Japan

7. Department of Clinical Sciences, Kumamoto University Hospital, Kumamoto, Japan

Abstract

Encouraged by our recent findings that 4′-cyano-deoxyguanosine (2), entecavir analogues 4 and 5 are highly potent anti-hepatitis B virus (HBV) agents, we designed and synthesized 6 having a hybridized structure of 4 and 5.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

National Cancer Institute

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01750H

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