Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

Author:

Serebryanskaya Tatiyana V.1234ORCID,Kinzhalov Mikhail A.567ORCID,Bakulev Vladimir567ORCID,Alekseev Georgii567,Andreeva Anastasiya567,Gushchin Pavel V.567,Protas Aleksandra V.567,Smirnov Andrey S.567ORCID,Panikorovskii Taras L.56789,Lippmann Petra10111213,Ott Ingo10111213ORCID,Verbilo Cyril M.1234,Zuraev Alexander V.1234ORCID,Bunev Alexander S.1415167ORCID,Boyarskiy Vadim P.567ORCID,Kasyanenko Nina A.567

Affiliation:

1. Research Institute for Physical Chemical Problems

2. Belarusian State University

3. 220006 Minsk

4. Belarus

5. Saint Petersburg State University

6. St. Petersburg

7. Russia

8. Laboratory of Nature-Inspired Technologies and Environmental Safety of the Arctic

9. Kola Science Centre

10. Institute of Medicinal and Pharmaceutical Chemistry

11. Technische Universität Braunschweig

12. D-38106 Braunschweig

13. Germany

14. Medicinal Chemistry Center

15. Togliatti State University

16. 445020 Togliatti

Abstract

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

Funder

Russian Foundation for Basic Research

Belarusian Republican Foundation for Fundamental Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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