Development of substituted benzylidene derivatives as novel dual cholinesterase inhibitors for Alzheimer's treatment

Author:

Gupta Shraddha Manish12,Behera Ashok3,Jain Neetesh K.1,Tripathi Avanish4,Rishipathak Dinesh5ORCID,Singh Siddharth2,Ahemad Nafees6,Erol Meryem7,Kumar Devendra8ORCID

Affiliation:

1. Faculty of Pharmacy, Oriental University, Indore 453555, Madhya Pradesh, India

2. Department of Pharmaceutical Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun 48007, India

3. Faculty of Pharmacy, School of Pharmacy and Population Health Informatics, DIT University, Makkawala, Dehradun, Uttarakhand, India

4. Institute of Pharmaceutical Research, GLA University, Mathura 281 406, U.P., India

5. Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Nasik, Maharashtra, India

6. School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Petaling Jaya 47500, Selangor DE, Malaysia

7. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey

8. School of Pharmacy & Technology Management, SVKM's NMIMS (Deemed-to-be) University, Mukesh Patel Technology Park, Shirpur 425405, India

Abstract

Leading pathological markers of Alzheimer's disease (AD) include Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), Amyloid beta (Aβ) and reactive oxygen species (ROS).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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