A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity-Reference-Cited by-同舟云学术

A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

Published:2020 Issue:34 Volume:56 Page:4716-4719
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yim Seo-Hee¹²³⁴,Cha Hyung Jin⁵⁶²³⁴^ORCID,Park Se-Jin¹²³⁴,Yim Yeajee¹²³⁴,Woo Jae-Sung⁵⁶²³⁴,Min Dal-Hee¹²³⁴⁷^ORCID

Affiliation:

1. Department of Chemistry

2. Seoul National University

3. Seoul 08826

4. Republic of Korea

5. Centre for RNA Research

6. Institute for Basic Science (IBS)

7. Department of Biological Sciences

Abstract

A fluorescent nanobiosensor for efficient quantitative analysis of the cancer-associated, m⁶A RNA demethylase ALKBH5 activity is developed, which shows high potential for robust anticancer drug screening against m⁶A RNA demethylase.

Funder

Institute for Basic Science

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC10054G

Reference19 articles.

1. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

2. Dynamic RNA Modifications in Gene Expression Regulation

3. A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

4. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

5. ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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