Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor-Reference-Cited by-同舟云学术

Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor

Published:2015 Issue:6 Volume:6 Page:1003-1017
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Istyastono Enade P.¹²³⁴⁵,Kooistra Albert J.¹²³⁴⁵,Vischer Henry F.¹²³⁴⁵,Kuijer Martien¹²³⁴⁵,Roumen Luc¹²³⁴⁵,Nijmeijer Saskia¹²³⁴⁵,Smits Rogier A.⁶⁵⁷,de Esch Iwan J. P.¹²³⁴⁵,Leurs Rob¹²³⁴⁵,de Graaf Chris¹²³⁴⁵

Affiliation:

1. Division of Medicinal Chemistry

2. Amsterdam Institute for Molecules, Medicines and Systems (AIMMS)

3. Faculty of Exact Sciences

4. VU University Amsterdam

5. 1081 HV Amsterdam

6. Griffin Discoveries B.V.

7. The Netherlands

Abstract

Structure-based virtual screening using H₁R- and β₂R-based histamine H₄R homology models identified 9 fragments with an affinity ranging from 0.14 to 6.3 μm for H₄R.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00022J

Reference109 articles.

1. Structural diversity of G protein-coupled receptors and significance for drug discovery

2. En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family

3. The Emerging Role of the Histamine H4 Receptor in Anti-inflammatory Therapy

4. Molecular Determinants of Selective Agonist and Antagonist Binding to the Histamine H4 Receptor

5. Major advances in the development of histamine H4 receptor ligands

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