Asymmetric hydrogenation of trifluoromethyl ketones: application in the synthesis of Odanacatib and LX-1031-Reference-Cited by-同舟云学术

Asymmetric hydrogenation of trifluoromethyl ketones: application in the synthesis of Odanacatib and LX-1031

Published:2021 Issue:14 Volume:8 Page:3705-3711
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhu Tiao-Zhen¹²³⁴,Shao Pan-Lin¹²³⁴^ORCID,Zhang Xumu⁵⁶²⁷⁴^ORCID

Affiliation:

1. College of Innovation and Entrepreneurship

2. Southern University of Science and Technology

3. Shenzhen 518055

4. China

5. Guangdong Provincial Key Laboratory of Catalysis

6. Department of Chemistry

7. Shenzhen

Abstract

The asymmetric hydrogenation of trifluoromethyl ketones via iridium catalysis to access chiral secondary 2,2,2-trifluoroethanols is presented. The key intermediates of Odanacatib and LX1301 were prepared with high yields and enantioselectivities.

Funder

Science, Technology and Innovation Commission of Shenzhen Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO00368B

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