Design and synthesis of imidazo[1,2-α][1,8]naphthyridine derivatives as anti-HCV agents via direct C

Design and synthesis of imidazo[1,2-α][1,8]naphthyridine derivatives as anti-HCV agents via direct C–H arylation

Published:2014 Issue:15 Volume:12 Page:2344-2348
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Huang Shengdian¹²³⁴⁵,Qing Jie¹⁶³⁴⁵,Wang Shuo¹²³⁴⁵,Wang Huan¹²³⁴⁵,Zhang Linqi¹⁶³⁴⁵,Tang Yefeng¹²³⁴⁵

Affiliation:

1. The Comprehensive AIDS Research Center

2. and The Department of Pharmacology and Pharmaceutical Sciences

3. School of Medicine

4. Tsinghua University

5. Beijing 100084, China

6. and The Department of Basic Medical Sciences

Abstract

Two series of analogues of RO8191, a potent anti-HCV agent, were synthesized via Pd-catalyzed, regioselective, single and double C–H arylations, respectively.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42525H

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