Microfluidic approach to correlate <i>C. elegans</i> neuronal functional aging and underlying changes of gene expression in mechanosensation-Reference-Cited by-同舟云学术

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Microfluidic approach to correlate C. elegans neuronal functional aging and underlying changes of gene expression in mechanosensation

Published:2024 Issue:10 Volume:24 Page:2811-2824
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Wan Jason¹^ORCID,Ding Jimmy L.²,Lu Hang¹²³^ORCID

Affiliation:

1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA

2. Petit Institute for Bioengineering and Bioscience, Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA

3. School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA

Abstract

This work presents a framework integrating microfluidic technologies to uncover aging-related insights. This platform allows for measuring physiological function and its associated gene expression through the aging process in C. elegans individuals.

Funder

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC01080E

Reference71 articles.

1. Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons

2. The aging neuromuscular system and motor performance

3. Factors contributing to the variability in muscle ageing

4. Control of rapid limb movements for balance recovery: age-related changes and implications for fall prevention

5. Molecular mechanisms of age-related hearing loss

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