The internal structure of gadolinium and perfluorocarbon-loaded polymer nanoparticles affects <sup>19</sup>F MRI relaxation times-Reference-Cited by-同舟云学术

The internal structure of gadolinium and perfluorocarbon-loaded polymer nanoparticles affects ¹⁹F MRI relaxation times

Published:2023 Issue:44 Volume:15 Page:18068-18079
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Mali Alvja¹²,Verbeelen Margot³,White Paul B.⁴,Staal Alexander H. J.³,van Riessen N. Koen¹³,Cadiou Cyril⁵,Chuburu Françoise⁵^ORCID,Koshkina Olga³⁶^ORCID,Srinivas Mangala¹⁷^ORCID

Affiliation:

1. Department of Cell Biology and Immunology, Wageningen University and Research, Wageningen, The Netherlands

2. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

3. Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

4. Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands

5. Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, Reims, France

6. Sustainable Polymer Chemistry Group, Department of Molecules and Materials, Mesa+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands

7. Cenya Imaging B.V., Amsterdam, The Netherlands

Abstract

The internal structure of PLGA nanoparticles loaded with perfluorocarbon and gadolinium affects 19F relaxation times. This modulated relaxation also makes the NPs sensitive to various acidic pH environments, while preserving their stability.

Funder

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR04577C

Reference46 articles.

1. 19F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

2. Fluorine (19F) MRS and MRI in biomedicine

3. Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer

4. Perfluorooctyl Bromide Polymeric Capsules as Dual Contrast Agents for Ultrasonography and Magnetic Resonance Imaging

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