Bexarotene cannot reduce amyloid beta plaques through inhibition of production of amyloid beta peptides:in silicoandin vitrostudy-Reference-Cited by-同舟云学术

Bexarotene cannot reduce amyloid beta plaques through inhibition of production of amyloid beta peptides:in silicoandin vitrostudy

Published:2018 Issue:37 Volume:20 Page:24329-24338
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Pham Huy Dinh Quoc¹²³⁴⁵,Thai Nguyen Quoc⁵⁶⁷⁸⁹,Bednarikova Zuzana¹⁰¹¹¹²¹³¹⁴,Linh Huynh Quang⁹¹⁵⁷⁸,Gazova Zuzana¹⁰¹¹¹²¹³¹⁴,Li Mai Suan¹²³⁴^ORCID

Affiliation:

1. Institute of Physics

2. Polish Academy of Sciences

3. 02-668 Warsaw

4. Poland

5. Institute for Computational Science and Technology

6. Quang Trung Software City

7. Ho Chi Minh City

8. Vietnam

9. Biomedical Engineering Department

10. Department of Biophysics

11. Institute of Experimental Physics

12. Slovak Academy of Sciences

13. 040 01 Kosice

14. Slovakia

15. University of Technology

Abstract

Recently, it has been reported that anti-cancer drug bexarotene can remarkably destroy amyloid beta (Aβ) plaques in mouse models suggesting therapeutic potential for Alzheimer's disease.

Funder

Narodowe Centrum Nauki

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP00049B

Reference50 articles.

1. Alzheimer's Disease: The Amyloid Cascade Hypothesis

2. Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

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4. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

5. BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

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