Speciation in human blood of Metvan, a vanadium based potential anti-tumor drug-Reference-Cited by-同舟云学术

Speciation in human blood of Metvan, a vanadium based potential anti-tumor drug

Published:2017 Issue:28 Volume:46 Page:8950-8967
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sanna Daniele¹²³^ORCID,Ugone Valeria⁴⁵⁶³,Micera Giovanni⁴⁵⁶³,Buglyó Péter⁷⁸⁹¹⁰,Bíró Linda⁷⁸⁹¹⁰,Garribba Eugenio⁴⁵⁶³^ORCID

Affiliation:

1. Istituto CNR di Chimica Biomolecolare

2. I-07040 Sassari

3. Italy

4. Dipartimento di Chimica e Farmacia

5. Università di Sassari

6. I-07100 Sassari

7. Department of Inorganic and Analytical Chemistry

8. University of Debrecen

9. H-4032 Debrecen Egyetem tér 1

10. Hungary

Abstract

The speciation of the anti-tumor drug Metvan, [V^IVO(Me₂phen)₂(SO₄)], suggested that forc(V) > 50 μM, [VO(Me₂phen)(citrH₋₁)]²⁻and the ternary complexes VO–Me₂phen–Protein should be the major species at pH 7.4, while forc(V) < 10 μM, (VO)(hTf) is formed, Me₂phen is lost and the conversion of V^IVO to V^VO/V^VO₂may occur.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C7DT00943G

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