Efficient synthesis of chiral 2,3-dihydro-benzo[b]thiophene 1,1-dioxides via Rh-catalyzed hydrogenation-Reference-Cited by-同舟云学术

Efficient synthesis of chiral 2,3-dihydro-benzo[b]thiophene 1,1-dioxides via Rh-catalyzed hydrogenation

Published:2019 Issue:8 Volume:10 Page:2507-2512
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Gongyi¹²³⁴⁵,Zhang Heng¹²³⁴⁵^ORCID,Huang Yi¹²³⁴⁵,Han Zhengyu¹²³⁴⁵,Liu Gang¹²³⁴⁵,Liu Yuanhua¹²³⁴⁵,Dong Xiu-Qin¹²³⁴⁵^ORCID,Zhang Xumu¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Biomedical Polymers

2. Engineering Research Center of Organosilicon Compounds & Materials

3. Ministry of Education

4. College of Chemistry and Molecular Sciences

5. Wuhan University

Abstract

Rh-Catalyzed asymmetric hydrogenation of substituted benzo[b]thiophene 1,1-dioxides was successfully developed. Both aromatic and alkyl substituted benzo[b]thiophene 1,1-dioxide substrates worked well with high yields and excellent enantioselectivities.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC05397A

Reference46 articles.

1. Synthesis and biological activity of trans-2,3-dihydroraloxifene

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3. Asymmetric Hydrogenation of Thiophenes and Benzothiophenes