Targeting <i>Pseudomonas aeruginosa</i> MvfR in the battle against biofilm formation: a multi-level computational approach-Reference-Cited by-同舟云学术

Targeting Pseudomonas aeruginosa MvfR in the battle against biofilm formation: a multi-level computational approach

Published:2022 Issue:10 Volume:7 Page:1294-1306
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Vieira Tatiana F.¹²^ORCID,Magalhães Rita P.¹²^ORCID,Cerqueira Nuno M. F. S. A.¹²^ORCID,Simões Manuel³⁴^ORCID,Sousa Sérgio F.¹²^ORCID

Affiliation:

1. UCIBIO/REQUIMTE, BioSIM – Departamento de Medicina, Faculdade de Medicina da Universidade Do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

2. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal

3. LEPABE Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal

4. ALiCE – Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal

Abstract

Computer aided drug design (CADD) methodology was used to discover new inhibitors of MvfR, an important quorum-sensing (QS) transcriptional regulator in Pseudomonas aeruginosa.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/ME/D2ME00088A

Reference61 articles.

1. Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

2. Molecular Insights into Binding Mode and Interactions of Structure-Based Virtually Screened Inhibitors for Pseudomonas aeruginosa Multiple Virulence Factor Regulator (MvfR)

3. Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution

4. Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds

5. In Silico Study of Ayapana Triplinervis Bioactive Compounds Against Quorum-Sensing System of Pseudomonas Aeruginosa

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