Elucidation of N-/O-glycosylation and site-specific mapping of sialic acid linkage isomers of SARS-CoV-2 human receptor angiotensin-converting enzyme 2

Author:

Wei Liming1ORCID,Chen Yuning23,Feng Xiaoxiao1,Yao Jun1,Zhang Lei1,Zhou Xinwen1,Yan Guoquan1,Qiu Hong23,Wang Chunhe23,Lu Haojie1ORCID

Affiliation:

1. Institutes of Biomedical Sciences and Department of Chemistry, Fudan University, 131 Dongan Road, 20032 Shanghai, China

2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences Department, 555 Zuchongzhi Road, 201203 Shanghai, China

3. School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, 100049 Beijing, China

Abstract

The N-/O-glycosylation and site-specific mapping of sialic acid linkage isomers of hACE2 were characterized, and which might give the clue for illustrating of the interaction between host cell and infection virus.

Funder

Shanghai Science and Technology Development Foundation

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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