Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders-Reference-Cited by-同舟云学术

Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders

Published:2023 Issue:21 Volume:15 Page:9348-9364
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Chen Yingxian¹²,Taufiq Tooba¹²,Zeng Niting³^ORCID,Lozano Neus⁴^ORCID,Karakasidi Angeliki¹²,Church Heather⁵,Jovanovic Ana⁶,Jones Simon A.⁵,Panigrahi Adyasha³,Larrosa Igor³,Kostarelos Kostas¹²⁴^ORCID,Casiraghi Cinzia³^ORCID,Vranic Sandra¹²^ORCID

Affiliation:

1. Nanomedicine Lab, Faculty of Biology, Medicine and Health, The University of Manchester, AV Hill Building, Manchester M13 9PT, UK

2. National Graphene Institute, The University of Manchester, Booth Street East, Manchester M13 9PL, UK

3. Department of Chemistry, University of Manchester, Oxford Road, Manchester, UK

4. Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain

5. Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Oxford Road, Manchester, UK

6. Adult Inherited Metabolic Department, Salford Royal NHS Foundation Trust, Manchester M6 8HD, UK

Abstract

Biocompatible cationic graphene flakes efficiently complex and deliver the enzyme to the lysosomes of the fibroblasts derived from the patients with Mucopolysaccharidosis VI, leading to enhanced degradation of the accumulated lysosomal substrate.

Funder

UK Research and Innovation

Engineering and Physical Sciences Research Council

University of Manchester

Manchester Collaborative Centre for Inflammation Research

Horizon 2020 Framework Programme

Generalitat de Catalunya

Agencia Estatal de Investigación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science