Significant role of Asn-247 and Arg-64 residues in close proximity of the active site in maintaining the catalytic function of CTX-M-15 type β-lactamase-Reference-Cited by-同舟云学术

Significant role of Asn-247 and Arg-64 residues in close proximity of the active site in maintaining the catalytic function of CTX-M-15 type β-lactamase

Published:2019 Issue:10 Volume:9 Page:5325-5337
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Maryam Lubna¹²³⁴⁵,Khalid Shamsi¹²³⁴⁵,Ali Abid¹²³⁴⁵,Khan Asad U.¹²³⁴⁵^ORCID

Affiliation:

1. Medical Microbiology and Molecular Biology Laboratory

2. Interdisciplinary Biotechnology Unit

3. Aligarh Muslim University

4. Aligarh

5. India

Abstract

Mutations of amino acid residues present near active site decrease the catalytic efficiency of beta lactamase enzymes.

Funder

Department of Biotechnology, Ministry of Science and Technology

Aligarh Muslim University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C8RA10313E

Reference33 articles.

1. Resistance in gram-negative bacteria: Enterobacteriaceae

2. Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

3. Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

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