Stereoselective synthesis of Gly-Gly-type (E)-methylalkene and (Z)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics-Reference-Cited by-同舟云学术

Stereoselective synthesis of Gly-Gly-type (E)-methylalkene and (Z)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics

Published:2020 Issue:49 Volume:10 Page:29373-29377
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Okita Hikari¹²³⁴⁵,Kato Yuna⁶⁷³⁴⁵,Masuzawa Tatsuki⁸⁷³⁴⁵,Arai Kosuke⁶⁷³⁴⁵,Takeo Sayuri¹²³⁴⁵,Sato Kohei¹²³⁴⁵^ORCID,Mase Nobuyuki¹²³⁴⁵^ORCID,Oyoshi Takanori⁸⁷³⁴⁵,Narumi Tetsuo¹²³⁴⁵

Affiliation:

1. Department of Applied Chemistry and Biochemical Engineering

2. Faculty of Engineering

3. Shizuoka University

4. Shizuoka

5. Japan

6. Department of Engineering

7. Graduate School of Integrated Science and Technology

8. Department of Chemistry

Abstract

An efficient synthesis of Gly-Gly-type (E)-methylalkene and (Z)-chloroalkene dipeptide isosteres is realized by organocuprate-mediated single electron transfer reduction.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA06554D

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3. Cobalt(III)-promoted hydrolysis of chelated glycine amides, glycylglycine, and glycylglycine esters. Kinetics and mechanism