Biosynthetic diversification of non-ribosomal peptides through activity-based protein profiling of adenylation domains-Reference-Cited by-同舟云学术

Biosynthetic diversification of non-ribosomal peptides through activity-based protein profiling of adenylation domains

Published:2023 Issue:62 Volume:59 Page:9473-9476
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ishikawa Fumihiro¹^ORCID,Tsukumo Natsumi¹,Morishita Erika¹,Asamizu Shumpei²^ORCID,Kusuhara Saaya¹,Marumoto Shinsuke³,Takashima Katsuki¹,Onaka Hiroyasu²,Tanabe Genzoh¹^ORCID

Affiliation:

1. Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

2. Graduate School of Agricultural and Life Sciences and Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan

3. Joint Research Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

Abstract

Coupled with precursor-directed biosynthesis, activity-based protein profiling of non-ribosomal peptide synthetases provides rational guidance for the biosynthetic diversification of non-ribosomal peptides.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC02633G

Reference25 articles.

1. Nonribosomal Peptide Synthesis-Principles and Prospects

2. A continuous kinetic assay for adenylation enzyme activity and inhibition

3. A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis

4. Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases

5. HAMA: a multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes