Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions

Author:

Hu Hao-Chun123ORCID,Yu Szu-Yin14,Tsai Yi-Hong5,Hsieh Pei-Wen367ORCID,Wang Hui-Chun1,Chen Yan-Ning1,Chuang Ya-Ting8,Lee Min-Yu9,Chang Hsueh-Wei8,Hu Hao-Chun1011,Wu Yang-Chang121314,Chang Fang-Rong1141516ORCID,Szatmári István2ORCID,Fülöp Ferenc2

Affiliation:

1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

2. Institute of Pharmaceutical Chemistry and HUN-REN-Stereochemistry Research Group, University of Szeged, Szeged 6720, Hungary

3. Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

4. Institute of Pharmacognosy, University of Szeged, Szeged 6720, Hungary

5. Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County 907101, Taiwan

6. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

7. Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan

8. Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

9. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

10. Department of Otorhinolaryngology-Head and Neck Surgery, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 242062, Taiwan

11. School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan

12. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan

13. Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan

14. Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

15. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

16. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan

Abstract

Mechanochemical reactions achieved by processes such as milling and grinding are promising alternatives to traditional solution-based chemistry.

Funder

Kaohsiung Medical University

National Pingtung University of Science and Technology

Hungarian Science Foundation

Emberi Eroforrások Minisztériuma

Richter Gedeon Talentum Alapítvány

National Science and Technology Council

Publisher

Royal Society of Chemistry (RSC)

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1. Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions;5th Symposium of Young Researchers on Pharmacognosy;2024

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