Synthesis of pyrazino[1,2-<i>b</i>]indazoles <i>via</i> cascade cyclization of indazole aldehydes with propargylic amines-Reference-Cited by-同舟云学术

Synthesis of pyrazino[1,2-b]indazoles via cascade cyclization of indazole aldehydes with propargylic amines

Published:2024 Issue:11 Volume:22 Page:2226-2230
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Zeng-Hui¹,Qu Heng-Tong¹,Han Ben-Jun¹,Yang Jia-Xin¹,Chang Xiang-Wei¹²,Feng Cheng-Tao¹^ORCID

Affiliation:

1. School of Pharmacy, Anhui University of Chinese Medicine, Anhui academy of Chinese medicine, Hefei, 230012, China

2. MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, China

Abstract

A cascade annulation of indazole aldehydes with propargylic amines has been developed to synthesize pyrazino[1,2-b]indazoles under additive-free conditions. Some pyrazino[1,2-b]indazoles exhibit significant antifungal activity.

Funder

Natural Science Foundation of Anhui Province

Anhui Department of Education

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00051J

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