Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation

Author:

Gao Yanan1,Xiao Jingyu1,Chen Zijian12,Ma Yutao1,Liu Xiaoya1,Yang Dishuang1,Leo Hwa Liang2,Yu Hanry3456,Kong Jian7ORCID,Guo Qiongyu1ORCID

Affiliation:

1. Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

2. Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore

3. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore

4. Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore

5. Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore 138669, Singapore

6. Singapore-MIT Alliance for Research and Technology, Singapore 138602, Singapore

7. Department of Interventional Radiology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China

Abstract

An orthotopic liver tumor spheroid model that captures the organ-level complexity of vasculature systems and the extracellular matrix is developed to evaluate transcatheter arterial chemoembolization treatment.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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