A versatile fluorinated azamacrocyclic chelator enabling <sup>18</sup>F PET or <sup>19</sup>F MRI: a first step towards new multimodal and smart contrast agents-Reference-Cited by-同舟云学术

A versatile fluorinated azamacrocyclic chelator enabling ¹⁸F PET or ¹⁹F MRI: a first step towards new multimodal and smart contrast agents

Published:2024 Issue:33 Volume:15 Page:13550-13557
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sire Charline¹^ORCID,Meneyrol Vincent²,Saffon-Merceron Nathalie³^ORCID,Terreno Enzo⁴^ORCID,Garello Francesca⁴^ORCID,Tei Lorenzo⁵^ORCID,Jestin Emmanuelle²,Tripier Raphaël¹^ORCID,Troadec Thibault¹^ORCID

Affiliation:

1. Univ. Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor Le Gorgeu, 29200 Brest, France

2. Cyclotron Réunion Océan Indien CYROI, 2 rue Maxime Rivière 97490 Sainte-Clotilde, France

3. Institut de Chimie de Toulouse (UAR 2599), 118 route de Narbonne, 31062 Toulouse Cedex 9, France

4. Department of Molecular Biotechnology and Health Sciences, University of Turin, Piazza Nizza 44/bis, 10126 Turin, Italy

5. Dipartimento di Scienze ed Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy

Abstract

A new trifluoroborate-appended macrocyclic chelator presents suitable 19F MRI signal and late-stage 18F-radiolabeling, paving the way for the design of novel theranostic and smart imaging agents.

Funder

Fondation ARC pour la Recherche sur le Cancer

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

Université de Bretagne Occidentale

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02871F

Reference50 articles.

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4. Fluorine (19F) MRS and MRI in biomedicine

5. Fluorinated Paramagnetic Complexes: Sensitive and Responsive Probes for Magnetic Resonance Spectroscopy and Imaging