Carbonized polymer dots derived from metformin and l-arginine for tumor cell membrane- and mitochondria-dual targeting therapy

Author:

Chen Manling1,Li Yang2,Liu Yangcheng3,Jia Baohua4,Liu Xue1ORCID,Ma Tianyi4ORCID

Affiliation:

1. Institute of Clean Energy Chemistry, Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, Shenyang 110036, Liaoning, P. R. China

2. Department of Cell Biology, Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, China Medical University, Shenyang 110122, Liaoning, P. R. China

3. School of Pharmaceutical Science, Liaoning University, Shenyang 110036, Liaoning, P. R. China

4. School of Science, STEM College, RMIT University, Melbourne, VIC 3000, Australia

Abstract

We first prepared carbonized polymer dots (MA-dots) from metformin and l-arginine to target the tumor cell membrane and mitochondria for antitumor therapy.

Funder

Shenyang Science and Technology Project

Department of Education of Liaoning Province

Australian Research Council

Cooperative Research Centres, Australian Government Department of Industry

Natural Science Foundation of Liaoning Province

Department of Science and Technology of Liaoning Province

China Scholarship Council

National Natural Science Foundation of China

Liaoning Revitalization Talents Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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