A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications

Author:

Swanson W. Benton1ORCID,Durdan Margaret23,Eberle Miranda14,Woodbury Seth14ORCID,Mauser Ava25,Gregory Jason26,Zhang Boya27,Niemann David146,Herremans Jacob14,Ma Peter X.1589,Lahann Joerg25689,Weivoda Megan2710,Mishina Yuji1,Greineder Colin F.2711

Affiliation:

1. Department of Biologic and Materials Science, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109, USA

2. Biointerfaces Institute, College of Engineering and Medical School, University of Michigan, Ann Arbor, MI, USA

3. Cell and Molecular Biology Program, Medical School, University of Michigan, Ann Arbor, MI, USA

4. Department of Chemistry, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, USA

5. Department of Biomedical Engineering, College of Engineering and Medical School, University of Michigan, Ann Arbor, MI, USA

6. Department of Chemical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA

7. Department of Pharmacology, Medical School, University of Michigan, Ann Arbor, MI, USA

8. Department of Materials Science and Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA

9. Macromolecular Science and Engineering Center, College of Engineering, University of Michigan, Ann Arbor, MI, USA

10. Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA

11. Department of Emergency Medicine, Medical School, University of Michigan, NCRC 2800 Plymouth Road, Bldg #26, Ann Arbor, MI 48109, USA

Abstract

Acidic pH is critical to the function of nearly every cell in the body. Based on Rhodamine 6G, we have developed a versatile molecular platform for non-invasive, real-time fluorescence imaging of acidic microenvironments based on Rhodamine 6G.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Reference90 articles.

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