Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea

Abstract

Total flavonoids in vine tea ameliorated AKT-induced nonalcoholic fatty liver disease in mice by targeting the PPAR signaling pathway, thereby regulating de novo fatty acid synthesis and glycerophospholipid metabolism.