Metal-free synthesis of secondary amides using N-Boc-O-tosylhydroxylamine as nitrogen source via Beckmann rearrangement

Author:

Jat Jawahar L.1ORCID,Kumar Puneet1,Verma Saumya1,Chandra Dinesh1,Singh Vikram2,Tiwari Bhoopendra2ORCID

Affiliation:

1. Department of Chemistry, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, India

2. Division of Molecular Synthesis & Drug Discovery, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow, India

Abstract

An efficient methodology for the direct synthesis of secondary amides from ketones has been developed by using N-Boc-O-tosylhydroxylamine (TsONHBoc).

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference56 articles.

1. Nitrogen insertion reactions of bridged bicyclic ketones. Regioselective lactam formation

2. R. J.Palmer , Encyclopedia of Polymer Science and Technology , Wiley , New York , 4th edn, 2001

3. A.Greenberg , C. M.Breneman and J. F.Liebman , The Amide Linkage: Structural Significance in Chemistry, Biochemistry, and Materials Science , John Wiley & Sons : New York , 2003

4. Analysis of the reactions used for the preparation of drug candidate molecules

5. Synthesis and structural analysis of 2-quinuclidonium tetrafluoroborate

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1. Metal-free synthesis of nitriles from aldehydes using N-Boc-O-tosylhydroxylamine as a nitrogen source;New Journal of Chemistry;2023

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