Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis-Reference-Cited by-同舟云学术

Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis

Published:2024 Issue:4 Volume:15 Page:1198-1209
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Wang Xin-Xin¹,Wang Run-Jie²,Ji Hua-Long¹,Liu Xiao-Yu³,Zhang Nai-Yu¹,Wang Kai-Ming¹,Chen Kai³,Liu Ping-Ping⁴,Meng Ning¹,Jiang Cheng-Shi¹^ORCID

Affiliation:

1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China

2. Key Laboratory of Forest Plant Ecology, Ministry of Education, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China

3. Evaluation Center of the New Drug, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China

4. Department of Gynaecology and Obstetrics, 960th Hospital of PLA, Jinan 250000, China

Abstract

This work designed and synthesized novel ferrostatin analogs with a benzohydrazide moiety, and identified compound 12 as a promising lead for preventing HG-induced VEC ferroptosis.

Funder

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Project of Shandong Province Higher Educational Science and Technology Program

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00038B

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