Development of a new approach for the synthesis of (+)-15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> methyl ester based on the [2+2]-cycloadduct of 5-trimethylsilylcyclopentadiene and dichloroketene-Reference-Cited by-同舟云学术

Development of a new approach for the synthesis of (+)-15-deoxy-Δ^12,14-prostaglandin J₂ methyl ester based on the [2+2]-cycloadduct of 5-trimethylsilylcyclopentadiene and dichloroketene

Published:2022 Issue:14 Volume:46 Page:6708-6714
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Gimazetdinov Airat M.¹^ORCID,Al’mukhametov Aidar Z.¹,Miftakhov Mansur S.¹

Affiliation:

1. Ufa Institute of Chemistry (UfIC), Ufa Federal Research Centre of the Russian Academy of Sciences (UFIC RAS) Pr. Oktyabrya, 71, Ufa, 450054, Russian Federation

Abstract

This paper described a first example of the application of the “abnormal” lactone of 3-oxabicyclo[3.3.0]oct-6-en-2-one topology in targeted prostaglandin synthesis.

Funder

Federal Agency for Scientific Organizations

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ01003H

Reference60 articles.

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2. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.

3. 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma.

4. Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

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1. Some aspects of the synthesis and modification of cross-conjugated cyclopentenone prostaglandins;Russian Chemical Bulletin;2023-10

2. A facile synthesis of (±)-15-deoxy-Δ12,14-prostaglandin J2 methyl ester;Mendeleev Communications;2023-07