Synthesis of hydrophilic HYNIC-[1,2,4,5]tetrazine conjugates and their use in antibody pretargeting with99mTc-Reference-Cited by-同舟云学术

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Synthesis of hydrophilic HYNIC-[1,2,4,5]tetrazine conjugates and their use in antibody pretargeting with99mTc

Published:2018 Issue:29 Volume:16 Page:5275-5285
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

García María Fernanda¹²³⁴⁵,Gallazzi Fabio⁶⁷⁸⁹,Junqueira Mara de Souza¹⁰¹¹¹²¹³¹⁴,Fernández Marcelo¹²³⁴⁵,Camacho Ximena¹²³⁴⁵,Mororó Janio da Silva¹⁰¹¹¹²¹³¹⁴,Faria Daniele¹⁵¹²¹³¹⁴,Carneiro Camila de Godoi¹⁵¹²¹³¹⁴,Couto Marcos¹⁶²³⁴⁵^ORCID,Carrión Federico¹⁷¹⁸¹⁹⁵,Pritsch Otto¹⁷¹⁸¹⁹⁵²⁰,Chammas Roger¹⁵¹²¹³¹⁴^ORCID,Quinn Thomas⁶⁷⁸⁹,Cabral Pablo¹²³⁴⁵,Cerecetto Hugo¹²³⁴⁵^ORCID

Affiliation:

1. Centro de Investigaciones Nucleares

2. Facultad de Ciencias

3. Universidad de la República

4. 11400 Montevideo

5. Uruguay

6. Department of Biochemistry

7. University of Missouri

8. Columbia

9. USA

10. Centro de Investigação Translacional em Oncologia

11. Instituto do Câncer do Estado de São Paulo

12. Faculdade de Medicina

13. Universidade de São Paulo

14. Brazil

15. Medicina Nuclear

16. Laboratorio de Química Orgánica

17. Unidad de Biofísica de Proteínas

18. Institut Pasteur de Montevideo

19. Montevideo

20. Depto. Inmunobiología

Abstract

Pretargeted imaging is shown to be an attractive strategy to overcome disadvantages associated with traditional radioimmunoconjugates.

Funder

Comisión Sectorial de Investigación Científica

University of Missouri

Universidade de São Paulo

Roche

Agencia Nacional de Investigación e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01255E

Reference60 articles.

1. Molecular Imaging in Cancer

2. Imaging in the era of molecular oncology

3. Antibody-Radionuclide Conjugates for Cancer Therapy: Historical Considerations and New Trends

4. Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer

5. Using antibodies to target cancer therapeutics

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