Ligand entry pathways control the chemical space recognized by GPR183

Author:

Kjær Viktoria Madeline Skovgaard1ORCID,Stępniewski Tomasz Maciej234ORCID,Medel-Lacruz Brian2,Reinmuth Lisa1,Ciba Marija5ORCID,Rexen Ulven Elisabeth5ORCID,Bonomi Massimiliano6,Selent Jana2ORCID,Rosenkilde Mette Marie1ORCID

Affiliation:

1. Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3B, 2200, København N, Denmark

2. Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM) & Pompeu Fabra University (UPF), Dr Aiguader 88, E-8003, Barcelona, Spain

3. InterAx Biotech AG, PARK innovAARE, 5234, Villigen, Switzerland

4. Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089, Warsaw, Poland

5. Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100, København Ø, Denmark

6. Institut Pasteur, Université Paris Cité, CNRS UMR3528, Structural Bioinformatics Unit, 75015, Paris, France

Abstract

The G protein-coupled receptor GPR183 utilizes two ligand entry channels: one lateral between transmembrane helices 4 and 5 facing the membrane, and one facing the extracellular environment to recognize chemically diverse ligands.

Funder

Instituto de Salud Carlos III

Danmarks Frie Forskningsfond

Lundbeck Foundation

Agència de Gestió d'Ajuts Universitaris i de Recerca

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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