Efficient synthesis of novel RGD based peptides and the conjugation of the pyrazine moiety to their N-terminus-Reference-Cited by-同舟云学术

Efficient synthesis of novel RGD based peptides and the conjugation of the pyrazine moiety to their N-terminus

Published:2019 Issue:6 Volume:43 Page:2702-2709
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Hamdan Fatima¹²³⁴,Bigdeli Zahra¹²³⁴,Balalaie Saeed¹²³⁴⁵^ORCID,Sewald Norbert⁶⁷⁸⁹¹⁰^ORCID,Michalek Carmela⁶⁷⁸⁹¹⁰

Affiliation:

1. Peptide Chemistry Research Center

2. K. N. Toosi University of Technology

3. Tehran

4. Iran

5. Medical Biology Research Center

6. Organic and Bioorganic Chemistry

7. Department of Chemistry

8. Bielefeld University

9. D-33615 Bielefeld

10. Germany

Abstract

Novel RGD based peptides (RGDFAKLF and RGDNGRG) were designed and synthesized and were later coupled to the pyrazine moiety at the N-terminus. The IC₅₀ values from the in vitro study of the target peptides using a cell adhesion assay indicated the essential impact of the existence of the pyrazine moiety. Meanwhile, peptide 4 exhibited the best IC₅₀ value.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C8NJ04874F

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