Total synthesis of MECA-79-Reference-Cited by-同舟云学术

Total synthesis of MECA-79

Published:2014 Issue:102 Volume:4 Page:58573-58580
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Behera Archanamayee¹²³,Emmadi Madhu¹²³,Kulkarni Suvarn S.¹²³

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology-Bombay

3. Mumbai, India

Abstract

MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation routethrough the intermediacy of Tn and TF antigens.

Funder

Council for Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA12631A

Reference29 articles.

1. The Tn Antigen-Structural Simplicity and Biological Complexity

2. The chemistry and biology of mucin-type O-linked glycosylation

3. A. Varki , R.Kannagi and B. P.Toole, Glycosylation Changes in Cancer, in Essentials of Glycobiology, ed. A. Varki, Cold Spring Harbor Laboratory Press, New York, 2nd edn, 2009

4. From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines

5. Synthesis of Tumor-Associated Glycopeptide Antigens

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Protecting Groups at the Secondary Positions of Carbohydrates;Protecting Groups;2018-11-19

2. “One-Pot” Protection, Glycosylation, and Protection–Glycosylation Strategies of Carbohydrates;Chemical Reviews;2018-06-05

3. Regioselective, One-Pot Functionalization of Carbohydrates;Selective Glycosylations: Synthetic Methods and Catalysts;2017-01-27

4. Scalable Synthesis of Anomerically Pure Orthogonal-Protected GlcN3 and GalN3 from d-Glucosamine;Organic Letters;2016-08-23