A combined therapy of rtPA-loaded thermoresponsive gels and ultrasound on hematoma in a rat model of intracerebral hemorrhage-Reference-Cited by-同舟云学术

A combined therapy of rtPA-loaded thermoresponsive gels and ultrasound on hematoma in a rat model of intracerebral hemorrhage

Published:2017 Issue:26 Volume:7 Page:15809-15816
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sun Wei¹²³⁴,Qian Zhongxin¹²³⁴,Zhao Mingzhu¹²³⁴,Shen Ming⁵⁶⁷⁸⁹,Duan Yourong⁵⁶⁷⁸⁹^ORCID,Liu Weidong¹²³⁴

Affiliation:

1. Department of Neurosurgery

2. Pu Nan Hospital

3. Shanghai 200125

4. China

5. State Key Laboratory of Oncogenes and Related Genes

6. Shanghai Cancer Institute

7. Renji Hospital

8. School of Medicine

9. Shanghai Jiao Tong University

Abstract

To develop and validate an effective method for the removal of residual intracerebral hematoma, we prepared a recombinant tissue-type plasminogen activator (rtPA)-loaded Pluronic F127 (NP-rtPA) delivery system to evaluate the neurological response of the ICH rat model.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA23150K

Reference28 articles.

1. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial

2. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial

3. Neuroendoscope-assisted evacuation of large intracerebral hematomas: introduction of a new, minimally invasive technique

4. Early mortality following spontaneous intracerebral hemorrhage

5. Endoscopic evacuation of putaminal hemorrhage: how to improve the efficiency of hematoma evacuation

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