Messenger RNA delivery by hydrazone-activated polymers-Reference-Cited by-同舟云学术

Messenger RNA delivery by hydrazone-activated polymers

Published:2019 Issue:7 Volume:10 Page:1138-1144
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Juanes Marisa¹²³⁴^ORCID,Creese Oliver⁵⁶⁷⁸^ORCID,Fernández-Trillo Paco⁵⁶⁷⁸^ORCID,Montenegro Javier¹²³⁴^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS)

2. Departamento de Química Orgánica

3. Universidade de Santiago de Compostela

4. Spain

5. School of Chemistry

6. University of Birmingham

7. Birmingham B15 2TT

8. UK

Abstract

Here we present the intracellular delivery of mRNA using polyhydrazones prepared in situ under physiological conditions, demonstrating the versatility and adaptability of this technology to more sensitive and therapeutically relevant nucleic acids.

Funder

Agencia Estatal de Investigación

Xunta de Galicia

European Regional Development Fund

Ministerio de Economía y Competitividad

University of Birmingham

Human Frontier Science Program

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00231F

Reference53 articles.

1. Gene therapy returns to centre stage

2. Gene therapy comes of age

3. Synthetic materials at the forefront of gene delivery

4. Delivery technologies for cancer immunotherapy

5. mRNA-based therapeutics — developing a new class of drugs

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Macromolecular Polymer Based Complexes: A Diverse Strategy for the Delivery of Nucleotides;Protein & Peptide Letters;2024-08-22

2. Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly;Molecules;2022-10-06

3. The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize;Molecular Therapy - Nucleic Acids;2022-09

4. Water‐Soluble (Poly)acylhydrazones: Syntheses and Applications;Macromolecular Chemistry and Physics;2022-05-18

5. Review: mRNA delivery systems in vaccinations and COVID-19;J RES PHARM;2022