Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cells-Reference-Cited by-同舟云学术

Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cells

Published:2020 Issue:1 Volume:11 Page:118-124
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Xu XiXi¹²³⁴,Roseblade Ariane¹²³⁴,Rawling Tristan¹²³⁴,Ung Alison T.¹²³⁴^ORCID

Affiliation:

1. School of Mathematical and Physical Sciences

2. Faculty of Science

3. University of Technology Sydney

4. Australia

Abstract

Tricyclic amides were successfully synthesised from β-caryophyllene via the Ritter reaction. Amides 3c and 6b inhibited proliferation of MDA-MB-231 cells. Compound 6b inhibited cell cycle progression and induced predominantly apoptotic cell death.

Funder

University of Technology Sydney

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00237E

Reference30 articles.

1. Alkaloids as drug leads – A predictive structural and biodiversity-based analysis

2. Impact of Natural Products on Developing New Anti-Cancer Agents

3. Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

4. Natural Products as Sources of New Drugs from 1981 to 2014

5. W. H. Organisation , World Cancer Report 2014 , International Agency for Research on Cancer , France , 2014 , pp. 362–369

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and biological evaluation of difluoroalkylated protoilludanes obtained by a practical radical cascade difluoroalkylation-cyclization reaction;Tetrahedron Letters;2022-01

2. Recent ring distortion reactions for diversifying complex natural products;Natural Product Reports;2022

3. Caryophyllene and caryophyllene oxide: a variety of chemical transformations and biological activities;Chemical Papers;2021-09-19

4. Recent advances of Ritter reaction and its synthetic applications;Organic Chemistry Frontiers;2021

5. A Concise Bioinspired Semisynthesis of Rumphellaones A–C and Their C-8 Epimers from β-Caryophyllene;Journal of Natural Products;2020-06-15