Design, synthesis and biological evaluation of novel C3-functionalized oxindoles as potential Pim-1 kinase inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of novel C3-functionalized oxindoles as potential Pim-1 kinase inhibitors

Published:2015 Issue:37 Volume:5 Page:29456-29466
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sun Hong-bao¹²³⁴⁵,Wang Xiao-yan⁶⁷⁸⁵,Li Guo-bo¹²³⁴⁵,Zhang Li-dan⁹⁷⁸⁵,Liu Jie¹²³⁴⁵,Zhao Li-feng¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center

2. West China Hospital

3. Sichuan University, and Collaborative Innovation Center for Biotherapy

4. Chengdu 610041

5. China

6. Analytical & Testing Center

7. Sichuan University

8. Chengdu 610064

9. College of Chemical Engineering

Abstract

A novel series of C3-functionalized oxindoles, 3-(2-oxo-4-phenylbut-3-en-1-ylidene) indolin-2-ones as potential Pim-1 kinase inhibitors, were designed, synthesized and investigated for inhibition of human cancer-cell proliferation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA00177C

Reference40 articles.

1. Physical and Functional Interactions between Pim-1 Kinase and Cdc25A Phosphatase

2. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C

3. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112gatekeeper site

4. PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

5. Pim-1 associates with protein complexes necessary for mitosis

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