Trifunctional fatty acid derivatives: the impact of diazirine placement

Author:

Farley Scotland E.12,Hashimoto Ryu13,Evangelista Judah12,Stein Frank4,Haberkant Per4,Kikuchi Kazuya3ORCID,Tafesse Fikadu G.2ORCID,Schultz Carsten1ORCID

Affiliation:

1. Oregon Health & Science University, Department of Chemical Physiology and Biochemistry, USA

2. Oregon Health & Science University, Department of Molecular Microbiology and Immunology, Portland, OR, 97239, USA

3. Osaka University, Department of Applied Chemistry, Graduate School of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

4. European Molecular Biology Laboratory, Proteomics Core Facility, 69117, Heidelberg, Germany

Abstract

Functionalized lipid probes are a critical new tool to interrogate the function of individual lipid species, but the structural parameters that constrain their utility have not been thoroughly described.

Funder

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

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