Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function

Author:

Sharma Shivani12,Porwal Konica1,Kulkarni Chirag12,Pal Subhashis1,Sihota Praveer3,Kumar Saroj3,Tiwari Mahesh Chandra1,Katekar Roshan42,Kumar Ashish4ORCID,Singh Priya1,Rajput Swati12,Guha Rajdeep5ORCID,Kumar Navin3,Gayen Jiaur R.4ORCID,Chattopadhyay Naibedya12ORCID

Affiliation:

1. Division of Endocrinology and Centre for Research in ASTHI, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

3. Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, 140001, India

4. Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India

5. Division of Laboratory Animal Facility, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India

Abstract

Kidney Disease Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline has recommended treatment decisions for patients with chronic kidney disease (CKD) with osteoporosis and/or high risk of fracture.

Funder

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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