The opening/closure of the P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib
Author:
Affiliation:
1. School of Chemistry and Chemical Engineering
2. Guangxi University
3. Nanning 530004
4. China
5. College of Life Science and Technology
6. School of Computer
7. Electronics and Information
Abstract
The open/closed conformations reveal the low/high bioactivities of the ligands.
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CP/C7CP03443A
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