Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces-Reference-Cited by-同舟云学术

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Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces

Published:2020 Issue:8 Volume:20 Page:1410-1417
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Abdalkader Rodi¹²³⁴,Kamei Ken-ichiro¹²³⁴^ORCID

Affiliation:

1. Institute for Integrated Cell-Material Sciences (WPI-iCeMS)

2. Kyoto University

3. Kyoto 606-8501

4. Japan

Abstract

Human corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/C9LC01256G

Reference28 articles.

1. Anatomy of the human corneal innervation

2. Human corneal cell culture models for drug toxicity studies

3. Cell culture models of the human cornea — a comparative evaluation of their usefulness to determine ocular drug absorption in-vitro

4. New Human Organotypic Corneal Tissue Model for Ophthalmic Drug Delivery Studies

5. The Effect of the Low Blink Rate in Rabbits on Topical Drug Penetration

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