Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate-Reference-Cited by-同舟云学术

Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate

Published:2014 Issue:15 Volume:50 Page:1817-1819
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Fabbiani Francesca P. A.¹²³⁴,Buth Gernot⁵⁶⁷,Levendis Demetrius C.⁸⁹¹⁰¹¹,Cruz-Cabeza Aurora J.¹²¹³¹⁴

Affiliation:

1. GZG

2. Abteilung Kristallographie

3. Georg-August-Universität Göttingen

4. Göttingen, 37077, Germany

5. Karlsruhe Institute of Technology

6. ANKA Synchrotron Radiation Facility

7. D-76344 Eggenstein-Leopoldshafen, Germany

8. Molecular Sciences Institute

9. School of Chemistry

10. University of the Witwatersrand

11. Johannesburg, South Africa

12. Van't Hoff Institute for Molecular Sciences

13. University of Amsterdam

14. 1098 XH Amsterdam, The Netherlands

Abstract

A monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4–0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations have been used to rationalise the experimental observations and gain an insight into thermodynamic stability.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C3CC48466A

Reference40 articles.

1. GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations

2. GABA, ?-hydroxybutyric acid, and neurological disease

3. The mechanisms of action of gabapentin and pregabalin

4. An historical perspective on GABAergic drugs

5. Conformations of γ-Aminobutyric Acid (GABA): The Role of the n→π* Interaction

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