A joint method for the screening of pharmacological chaperones for phenylalanine hydroxylase-Reference-Cited by-同舟云学术

A joint method for the screening of pharmacological chaperones for phenylalanine hydroxylase

Published:2021 Issue:26 Volume:19 Page:5827-5835
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang Zhilei¹²³⁴⁵^ORCID,Ma Dingyuan¹²³⁴⁵,Wang Xin¹²³⁴⁵,Wang Yanyun¹²³⁴⁵,Li Yahong¹²³⁴⁵,Yang Peiyin¹²³⁴⁵,Sun Yun¹²³⁴⁵,Jiang Tao¹²³⁴⁵^ORCID,Xu Zhengfeng¹²³⁴⁵

Affiliation:

1. The affiliated Obstetrics and Gynecology Hospital with Nanjing Medical University

2. Nanjing Maternity and Child Health Care Hospital

3. Center of Genetic Medicine

4. Nanjing 210004

5. P.R. China

Abstract

In this study, we established a joint method for the drug screening of PAH patients by combining magnetic beads-based immune-affinity capturing, VS, and MS/MS analysis which is cost-effective, labor-saving, time-saving and high reliability.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00638J

Reference39 articles.

1. Phenylketonuria: Current Treatments and Future Developments

2. The complete European guidelines on phenylketonuria: diagnosis and treatment

3. The Prevalence of Phenylketonuria in Arab Countries, Turkey, and Iran: A Systematic Review

4. Systematic Review and Meta-Analysis of Neuropsychiatric Symptoms and Executive Functioning in Adults With Phenylketonuria

5. PKU dietary handbook to accompany PKU guidelines

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