Drug encapsulation and release with a nonionic amphiphilic calix[4]pyrrole

Author:

Mirabolghasemi Mana1,Bektas Necla1,Sancakli Buse2,Dag Aydan3,Aydogan Abdullah1ORCID

Affiliation:

1. Department of Chemistry, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey

2. Department of Biotechnology, Institute of Health Sciences, Bezmialem Vakif University, Istanbul 34093, Turkey

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul 34093, Turkey

Abstract

A nonionic amphiphilic calix[4]pyrrole compound was synthesized and used to prepare stable micelles in water. These micelles were then shown to effectively encapsulate and release doxorubicin under acidic and basic medium.

Funder

Bilimsel Araştırma Projeleri Birimi, İstanbul Teknik Üniversitesi

Publisher

Royal Society of Chemistry (RSC)

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