Self-oxidation of cysteine to sulfinic acid in an engineered T67C myoglobin: structure and reactivity-Reference-Cited by-同舟云学术

Self-oxidation of cysteine to sulfinic acid in an engineered T67C myoglobin: structure and reactivity

Published:2023 Issue:5 Volume:4 Page:330-333
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Dai Wei¹,Yuan Hong²,Wang Xiao-Juan¹,Gao Shu-Qin³,Tan Xiangshi²^ORCID,Lin Ying-Wu¹³^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China

2. Department of Chemistry & Institute of Biomedical Science, Fudan University, Shanghai 200433, China

3. Key Lab of Protein Structure and Function of Universities in Hunan Province, University of South China, Hengyang 421001, China

Abstract

An engineered T67C myoglobin mutant undergoes self-oxidation of Cys67 to a sulfinic acid (Cys–SO2H), as confirmed by the X-ray crystal structure, which provides a useful platform to generate artificial proteins by further chemical modifications.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00007A

Reference35 articles.

1. Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

2. Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology

3. Proteome‐Wide Survey of Cysteine Oxidation by Using a Norbornene Probe

4. Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells

5. Heme Enzyme Structure and Function

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