A dimeric α-helical cell penetrating peptide mounted with an HER2-selective affibody-Reference-Cited by-同舟云学术

A dimeric α-helical cell penetrating peptide mounted with an HER2-selective affibody

Published:2021 Issue:23 Volume:9 Page:7826-7831
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Chong Seung-Eun¹,Lee Donghyun²,Oh Jae Hoon³,Kang Sunyoung¹,Choi Sejong¹,Nam So Hee¹,Yu Jaehoon⁴^ORCID,Koo Heebeom²^ORCID,Lee Yan¹^ORCID

Affiliation:

1. Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea

2. Department of Medical Life Sciences and Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, Republic of Korea

3. Department of Engineering, Kyoto University Katsura, Kyoto, 615-8530, Japan

4. Department of Chemistry & Education, Seoul National University, Seoul, 08826, Republic of Korea

Abstract

With the combination of a powerful cell penetrating peptide (CPP: LK-2) and an HER2-selective affibody (ZHER2:342), LK-2-ZHER2:342 showed remarkable selectivity on HER2-overexpressed cancer cells at nanomolar concentrations.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00819F

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