Dissecting phospho-motif-dependent Shc1 interactome using long synthetic protein fragments

Author:

Chen Peizhong12,Chen Xiong13,Song Xiaolei4,He An1,Zheng Yong45,Li Xuechen2ORCID,Tian Ruijun134ORCID

Affiliation:

1. Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China

2. Department of Chemistry, State Key Lab of Synthetic Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China

3. Shenzhen Key Laboratory of Functional Proteomics, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, 518055, China

4. State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China

5. Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, School of Basic Medicine, School of Rehabilitation Medicine, Gannan Medical University, Ganzhou, 341000, China

Abstract

A series of long synthetic peptides with different phosphorylation were assembled chemically for AP-MS profiling of the site specific interactome of Shc1CH1, and active signal probing in cell lines with different expression level of EGFR and HER2.

Funder

National Natural Science Foundation of China

Science, Technology and Innovation Commission of Shenzhen Municipality

Publisher

Royal Society of Chemistry (RSC)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3